货号：09-482

品牌：Merck Millipore

规格：100UL

目录价：￥4592.00

市场价格：￥3903.20

会员价格：￥3673.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PI3 Kinase Antibody, p110β | 09-482 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Recognizes the internal domain of PI3 Kinase, p110β. View All» Molecular Weight: 110 kDa View All» Epitope: Internal Domain View All» Immunogen: KLH-conjugated synthetic linear peptide corresponding to the internal domain of PI3 Kinase, p110β. View All» Background Information: PI3 Kinase (Phosphatidylinositol 3-Kinase) is responsible for phosphorylation of the 3 position of the inositol ring of PI(4,5)P2, to generate PI(3,4,5)P3, a potent second messenger required for survival, signaling, and insulin action. PI3 Kinase is a heterodimeric complex composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. Tyrosine phosphorylation of growth factor receptors creates docking sites for binding of p85 (through its SH2 domains) on the receptors; p85 brings with it p110, which is then proximal to its phospho-lipid substrate on the membrane. PI3 Kinase is also activated by Ras, and by the β:γ subunits of heterotrimeric G-proteins. PI3 Kinase is inhibitable by wortmannin, a useful tool for the study of the PI3 Kinase signaling pathway. View All» Species Reactivity:

• Human

• Monkey

• Canine

• Mouse

• Rat
  View All» Species Reactivity Note: Human. Expected to react with Monkey, Dog, Rat and Mouse based on immunogen sequence homology. View All» Application Notes: ELISA: This antibody was tested and determined to work for ELISA at 0.5 ng/well. View All» Control: HEK-293 cell lysate. View All» Quality Assurance: Evaluated by Western Blot on HEK-293 cell lysate.Western Blot Analysis: 0.05 - 0.1 μg/mL of this antibody detected endogenous PI3 Kinase, p110β in lysate from HEK-293 cells. View All» Purification Method: Affinity Purfied View All» Presentation: Antigen affinity purified rabbit serum in 0.1M Tris-Glycine (pH7.4), 150mM NaCl, with 0.05% NaN3. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. View All» UniProt Number: P42336 View All» Entrez Gene Number: NP_006210.1 View All» Gene Symbol:
  • EC 2.7.1.153

  • MGC142161

  • MGC142163

  • PI3K

  • p110-alpha
    View All» Alternate Names:
    • PI3-kinase p110 subunit alpha

    • phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha

    • PtdIns-3-kinase p110

    • phosphatidylinositol 3-kinase, catalytic, alpha polypeptide

    • phosphatidylinositol-4,5-bisphosphate 3-kinase catalyticsubunit, alpha isoform

    • phosphoinositide-3-kinase, catalytic, alpha polypeptide
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation

      • Immunocytochemistry

      • Immunohistochemistry

      • ELISA
        View All» UniProt Summary: FUNCTION: Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.SUBUNIT STRUCTURE: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Binds to IRS1 in nuclear extracts. Interacts with RUFY3 By similarity.INVOLVEMENT IN DISEASE: Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500].Defects in PIK3CA are associated with breast cancer [MIM:114480].Defects in PIK3CA are associated with epithelial ovarian cancer (EOC) [MIM:604370].Defects in PIK3CA may underlie hepatocellular carcinoma (HCC) [MIM:114550]. Ref.14PI3KCA mutations affecting exons 9 and 20 display gender- and tissue-specific patterns, thus suggesting that the different amino acid changes could exert distinct functional effects on the oncogenic properties of this enzyme. Furthermore, sexual dimorphisms and tissue specific factors might directly or indirectly influence the occurrence of PI3KCA cancer alleles.SEQUENCE SIMILARITIES: Belongs to the PI3/PI4-kinase family.Contains 1 C2 domain.Contains 1 PI3K/PI4K domain. View All» Product Name: Anti-PI3 Kinase Antibody, p110β | 09-482 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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