金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived, Arg30-Val200, with the variant of Lys74Arg and a C-terminal 6-His tag Accession #:AAN28264 N-terminal Sequence Analysis:Arg30 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:20.1 kDa SDS-PAGE:22 kDa, reducing conditions Activity:Measured in an anti-viral assay using HepG2 human hepatocellular carcinoma cells infected with encephalomyocarditis (EMC) virus. Sheppard, P. et al. (2003) Nat. Immunol. 4:63.The ED₅₀ for this effect is typically 1 - 5 ng/mL. Molecule Information: IL-28B/IFN-lambda 3 Long Name: Interleukin 28B Aliases: IFN-lambda 3 Entrez Gene IDs: 282617 (Human); 338374 (Mouse) Background: IL-28 & IL-29 Human/mouse IL-28A (IFN-lambda 2), IL-28B (IFN-lambda 3), and human IL-29 (IFN-lambda 1) are class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11 - 13% amino acid (aa) sequence identity) and type I IFN family (15 - 19% aa sequence identity). These cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and up-regulation of MHC class I antigen expression. The proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor beta (IL-10 R beta) and a novel IL-28 receptor alpha (IL-28 R alpha, also known as IFN-lambda R1). Mouse IL-28 shares 61%, 62%, and 52% aa identity with human IL-28A, IL-28B, and IL-29, respectively.