货号：09-796

品牌：Merck Millipore

规格：100Ug

目录价：￥5207.00

市场价格：￥4425.95

会员价格：￥4165.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PADI4 Antibody, C-terminus | 09-796 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes PADI4 at and around the C-terminus. View All» Molecular Weight: ~74 kDa View All» Epitope: C-terminus View All» Immunogen: KLH-conjugated synthetic linear peptide corresponding to the C-terminal region of PADI4. View All» Background Information: PADI4 (Protein-arginine deiminase type-4) is a member of a family of enzymes responsible for the conversion of arginine residues to citrulline residues via catalysis of the deimination of the arginine residues. PADI4 down-regulates histone H3 and H4 arginine methylation, both by preventing arginine methylation by CARM1 and HRMT1L2/PRMT1 and by converting methylarginine to citrulline. This protein may play a role in granulocyte and macrophage development leading to inflammation and immune response. View All» Species Reactivity: Human View All» Species Reactivity Note: Human View All» Application Notes: ELISA: A 1:1000 dilution of a previous lot was used on ELISA. View All» Control: HEK293 cell lysate View All» Quality Assurance: Evaluated by western blot on HEK293 cell lysate.Western Blotting Analysis: 1:25-1:500 dilution of this antibody detected PADI4 in HEK293 cell lysate. View All» Purification Method: Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. View All» Presentation: Purified rabbit polyclonal in buffer containing PBS and 0.09% sodium azide. View All» Storage Conditions: Stable for 6 months at 2-8ºC from date of receipt. For long term storage, store at -20ºC View All» UniProt Number: Q9UM07 View All» Entrez Gene Number: NP_036519 View All» Gene Symbol:

• PADI4

• PAD

• PAD4

• PADI5

• PDI4

• PDI5
  View All» Alternate Names:
  • HL-60 PAD

  • PADI-H protein

  • Peptidylarginine deiminase IV

  • Protein-arginine deiminase type IV

  • peptidyl arginine deiminase, type IV

  • peptidyl arginine deiminase, type V

  • protein-arginine deiminase

  • Protein-arginine deiminase type-4
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • ELISA
      View All» Entrez Gene Summary: This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response.[provided by RefSeq]. View All» UniProt Summary: FUNCTION: Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at 'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1. CATALYTIC ACTIVITY: Protein L-arginine + H2O = protein L-citrulline + NH3.COFACTOR: Binds 5 calcium ions per subunit. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasmic granule. Note= Cytoplasmic granules of eosinophils and neutrophils. TISSUE SPECIFICITY: Expressed in eosinophils and neutrophils, not expressed in peripheral monocytes or lymphocytes. INVOLVEMENT IN DISEASE: PADI4 is thought to be a rheumatoid arthritis susceptibility locus [MIM:180300]. Could have an important role in the pathogenesis of rheumatoid arthritis by increasing citrullination of proteins in rheumatoid arthritis synovial tissues, leading, in a cytokine-rich milieu, to a break in tolerance to citrullinated peptides processed and presented in the appropriate HLA context. SEQUENCE SIMILARITIES: Belongs to the protein arginine deiminase family.BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters:KM=0.055 mM for fibrinogenKM=0.064 mM for filaggrinVmax=33.2 µmol/h/mg enzyme toward fibrinogenVmax=8.0 µmol/h/mg enzyme toward filaggrinpH dependence:Optimum pH is 6.5-9.0. View All» Product Name: Anti-PADI4, C-terminus View All» Concentration: 0.25 µg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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