货号：09-822

品牌：Merck Millipore

规格：100UL

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-KLF5 (Krüppel-like factor 5) Antibody | 09-822 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Krüppel-like factor 5 at the N-terminus. View All» Molecular Weight: ~55 kDa observed. An uncharacterized band appears at ~30 kDa. View All» Epitope: N-terminus View All» Immunogen: Recombinant protein corresponding to mouse Krüppel-like factor 5 at the N-terminus. View All» Background Information: Krüppel-like factors (KLFs) are zinc finger-containing transcription factors with regulatory functions in cell growth, proliferation, differentiation, and embryogenesis. KLF5, (also known as BTEB2 and IKLF), is essential for mouse embryo development. KLF5 activates many genes during cardiovascular remodeling, including PDGFa/b, Egr-1, PAI-1, iNOS, and VEGF receptors, making KLF a potential therapeutic target for cardiovascular disease. KLF5 also plays a role in angiogenesis and in development of several tumor types including breast, prostate, bladder, colon, esophagus, and skin. KLF5 is closely related to other of the KLF family members. However, KLF5 and KLF4 exhibit opposite effects on regulation of gene transcription, despite binding to similar, if not identical, cis-acting DNA sequences. In addition, KLF4 and 5 exert contrasting effects on cell proliferation in many instances; while KLF4 is an inhibitor of cell growth, KLF5 stimulates proliferation. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with mouse. View All» Application Notes: Chromatin Immunoprecipitation Analysis (ChIP): A representative lot was used by an independent laboratory in ChIP. (Ng Huck Hui, Genome Institute of Singapore) View All» Control: Mouse embryonic stem cell chromatin extract View All» Quality Assurance: Evaluated by Western Blot in mouse embryonic stem cell chromatin extract.Western Blot Analysis: 1:2,000 dilution of this antibody detected Krüppel-like factor 5 on 10 µg of mouse embryonic stem cell chromatin extract. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal serum containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q9Z0Z7 View All» Entrez Gene Number: NP_033899 View All» Gene Symbol:

• KLF5

• CKLF

• BTEB2

• IKLF
  View All» Alternate Names:
  • BTE-binding protein 2

  • Basic transcription element-binding protein 2

  • Colon krueppel-like factor

  • GC box binding protein 2

  • GC-box-binding protein 2

  • Intestinal-enriched krueppel-like factor

  • Kruppel-like factor 5

  • Kruppel-like factor 5 (intestinal)

  • Transcription factor BTEB2

  • basic transcription element binding protein 2

  • colon kruppel-like factor

  • intestinal-enriched kruppel-like factor
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.SUBUNIT STRUCTURE: Interacts with WWP1 (By similarity).SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICTY: Highest expression in digestive track.PTM: Ubiquitinated (By similarity). Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.SEQUENCE SIMILARITIES: Belongs to the krueppel C2H2-type zinc-finger protein family.Contains 3 C2H2-type zinc fingers. View All» Product Name: Anti-KLF5 (Krüppel-like factor 5) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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