货号：09-827

品牌：Merck Millipore

规格：100Ug

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-HDAC11 Antibody | 09-827 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes HDAC11. View All» Molecular Weight: 39 kDa View All» Epitope: Amino Acid: 228-246 View All» Immunogen: Linear Peptide corresponding to human HDAC11 at amino acids 228-246. View All» Background Information: HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation is a marker for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. View All» Application Notes: Western Blot (SNAP ID) Analysis: 0.5 µg/ml from a representative lot detected HDAC11 on 10 µg of human brain tissue lysate. View All» Control: Human brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human brain tissue lysate.Western Blot Analysis: 0.05 µg/ml of this antibody detected HDAC11 on 10 µg of human brain tissue lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q96DB2 View All» Entrez Gene Number: NP_079103.2 View All» Gene Symbol:
  • HDAC11

  • HD11
    View All» Alternate Names: histone deacetylase 11 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants. View All» UniProt Summary: FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.SUBUNIT STRUCTURE: Interacts with HDAC6. SUBCELLULAR LOCATION: Nucleus. Note: Predominantly nuclear.TISSUE SPECIFICTY: Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.MISCELLANEOUS: Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.SEQUENCE SIMILARITIES: Belongs to the histone deacetylase family.SEQUENCE CAUTION: The sequence BAB15127.1 differs from that shown. Reason: Erroneous termination at position 107. Translated as Gln.The sequence CAB70712.1 differs from that shown. Reason: Frameshift at positions 177, 198 and 200. View All» Product Name: Anti-HDAC11 Antibody (09-827) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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