金山科研平台，产品价格货期咨询微信：jinshanbio Source:E. coli-derived, Ala26-Gln104 Accession #:CAA43461 N-terminal Sequence Analysis:Ala26 Purity:>97%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:9.4 kDa Activity:Measured by its ability to induce myeloperoxidase release from cytochalasin B-treated human neutrophils. Schröder, J.M. etal. (1987) J.Immunol. 139:3474.The ED₅₀ for this effect is typically 0.4-0.6µg/mL.Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CXCR2.The ED₅₀ for this effect is typically 1 - 5 ng/mL. Molecule Information: CXCL8/IL-8 Aliases: GCP1; IL8; LAI; MDNCF; NAP1; NCF; TCF; TSG1 Entrez Gene IDs: 3576 (Human); 396880 (Porcine); 403850 (Canine); 493836 (Feline) Background: CXCL8/IL-8

CXCL8 is a potent chemoattractant for neutrophils. In addition, CXCL8 also has a wide range of other proinflammatory effects. CXCL8 causes degranulation of neutrophil specific granules and azurophilic granules. CXCL8 induces expression of the cell adhesion molecules CD11/CD18 and enhances the adherence of neutrophils to endothelial cells and subendothelial matrix proteins. Besides neutrophils, CXCL8 is also chemotactic for basophils, T cells and eosinophils. CXCL8 has been reported to be a co-mitogen for keratinocytes and was also shown to be an autocrine growth factor for melanoma cells. CXCL8 was also reported to be angiogenic both in vivo and in vitro.