货号：09-833

品牌：Merck Millipore

规格：EA

目录价：￥4164.00

市场价格：￥3539.40

会员价格：￥3331.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MBD1 (methyl-CpG binding domain protein 1) Antibody | 09-833 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes MBD1 View All» Molecular Weight: 60 kda View All» Epitope: a.a. 96-113 View All» Immunogen: KLH conjugated synthetic peptide (RKRQVGPQSGEVRKEAPR(C) corresponding to a.a. 96-113 of human MBD1. View All» Isotype: IgG View All» Background Information: MBD1 (methyl-CpG binding domain protein 1) is a transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. MBD1 is part of the MeCP1 complex where it acts as a transcriptional repressor and plays a role in gene silencing. MBD1 forms a complex with the histone methyltransferase SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone Lys-9 trimethylation. During DNA replication, it recruits SETDB1 to form a S phase-specific complex that facilitates methylation of Lys9 on histone H3 during replication-coupled chromatin assembly. MBD1 is associated with euchromatic regions of the chromosomes and with telomeric regions View All» Species Reactivity: Human View All» Species Reactivity Note: Human View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Purification Method: Immunoaffinity purified View All» Presentation: Immunoaffinity purified rabbit IgG in PBS containing 0.1% sodium azide, 30% glycerol View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance View All» UniProt Number: Q9UIS9 View All» Entrez Gene Number:

• NM_012117.1

• 4152
  View All» Gene Symbol:
  • CXXC3

  • CXXC-type zinc finger protein 3

  • Methyl-CpG-binding protein MBD1

  • Regulator of fibroblast growth factor 2 (FGF-2) transcription 2

  • PCM1

  • MBD1
    View All» Alternate Names: Methyl-CpG-binding domain protein 1 PCM1RFT CXXC3 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. Five transcript variants of the MBD1 are generated by alternative splicing resulting in protein isoforms that contain one MBD domain, two to three cysteine-rich (CXXC) domains, and some differences in the COOH terminus. All five transcript variants repress transcription from methylated promoters; in addition, variants with three CXXC domains also repress unmethylated promoter activity. MBD1 and MBD2 map very close to each other on chromosome 18q21. View All» UniProt Summary: Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. View All» Brand Family: Upstate View All» Product Name: Anti-MBD1 (methyl-CpG binding domain protein 1) Antibody | 09-833 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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