R&D Systems代理5360-NP-050 Recombinant Human Neuroplastin 65 Protein, CF (50 UG)

2025-06-27

货号:5360-NP-050

品牌:R&D Systems

规格:50ug

目录价:¥4490.00

市场价格:¥3592.00

会员价格:¥3592.00

  • 到货时间:3~4周

    金山科研平台,产品价格货期咨询微信:jinshanbio Source:Mouse myeloma cell line, NS0-derived, Gln29-His336, with a C-terminal 6-His tag Accession #:Q9Y639 N-terminal Sequence Analysis:Gln29 predicted: No results obtained, sequencing might be blocked Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:35.5 kDa SDS-PAGE:45-60 kDa, reducing condtions Activity:Measured by the ability of the immobilized protein to support the adhesion of A431 human epithelial carcinoma cells.The ED50 for this effect is typically 1.1-4.4 µg/mL.Optimal dilutions should be determined by each laboratory for each application. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: Neuroplastin 65 Aliases: Np65 Entrez Gene IDs: 27020 (Human); 56064 (Rat) Background: Neuroplastin 65

    View Neuroplastin 65 IHC images. Neuroplastin (NPTN; also stromal cell-derived receptor 1 and Np55) is a 52 - 57 kDa member of the Ig-superfamily. Neuroplastin is widely expressed and likely serves as a cell adhesion molecule in multiple tissues. Human Neuroplastin is 282 amino acids (aa) in length. It is a type I transmembrane glycoprotein that contains two Ig-like domains (aa 32 - 119 and 122 - 213) and a 38 aa cytoplasmic region (aa 245 - 282).

    There is a brain-enriched 65 kDa form of Neuroplastin 65 (Np65) that negatively regulates LTP in the hippocampus. Neuroplastin 65 contains an N-terminal 116 aa Ig-like domain-containing insert after Asn30 and interacts homotypically. Notably, human and rodent Np65 expression patterns are different in brain, with rodent Np65 not predominating in cerebellum. Over aa 29 - 336, human Np65 is 95% aa identical to mouse Np65.

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