货号：09-860

品牌：Merck Millipore

规格：100UL

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DDX3X Antibody | 09-860 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody detects RNA-binding protein DDX3X. View All» Molecular Weight: ~73 kDa View All» Immunogen: KLH-conjugated synthetic linear peptide corresponding to DDX3X. View All» Background Information: DDX3X, DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked, is a member of the DEAD box family of proteins. Characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), DEAD box proteins are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. DDX3X is an ATP-dependent RNA helicase and acts as a co-factor for XPO1-mediated nuclear export of incompletely spliced HIV-1 Rev RNAs. DDX3X is also involved in HIV-1 replication and interacts specifically with hepatitis C virus core protein resulting in a change in intracellular location. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Tested on human, mouse and rat. View All» Control: A431 cell lysate View All» Quality Assurance: Evaluated by western blot on A431 cell lysate.Western Blot Analysis: 1:1000 dilution of this antibody detected DDX3X in A431 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal serum with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: O00571 View All» Entrez Gene Number: NP_001347.3 View All» Gene Symbol:
  • CAP-Rf

  • DBX

  • DDX14

  • DDX3

  • EC 3.6.1.-

  • HLP2
    View All» Alternate Names:
    • ATP-dependent RNA helicase DDX3X

    • DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked

    • DEAD box protein 3, X-chromosomal

    • DEAD box, X isoform

    • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3

    • DEAD/H box-3

    • Helicase-like protein 2

    • helicase like protein 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which interacts specifically with hepatitis C virus core protein resulting a change in intracellular location. This gene has a homolog located in the nonrecombining region of the Y chromosome. The protein sequence is 91% identical between this gene and the Y-linked homolog. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: ATP-dependent RNA helicase. Acts as a cofactor for XPO1-mediated nuclear export of incompletely spliced HIV-1 Rev RNAs. Also involved in HIV-1 replication. Interacts specifically with hepatitis C virus core protein resulting in a change in intracellular location.SUBUNIT STRUCTURE: Found in a complex with Rev and XPO1. Interacts with XPO1 and TDRD3. Interacts with HCV core protein. SUBCELLULAR LOCATION: Nucleus speckle. Cytoplasm. Note: Located predominantly in nuclear speckles and, at low levels, throughout the cytoplasm. Located to the outer side of nuclear pore complexes (NPC). Shuttles between the nucleus and the cytoplasm in a XPO1-dependent manner. SEQUENCE SIMILARITIES: Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.Contains 1 helicase ATP-binding domain.Contains 1 helicase C-terminal domain. View All» Product Name: Anti-DDX3X Antibody View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Serum View All» Host: Rabbit View All»
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