货号：09-862

品牌：Merck Millipore

规格：

目录价：￥4739.00

市场价格：￥4028.15

会员价格：￥3791.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Histone H2A.Z Antibody | 09-862 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Histone H2A.Z. View All» Molecular Weight: ~15 kDa View All» Epitope: C-terminus View All» Immunogen: The immunogen was a linear peptide corresponding to C-terminal amino acids 113-127 of human Histone H2A.Z. View All» Background Information: H2A.Z, also known as H2AFZ, is a variant of histone H2A variant that is highly conserved from yeast to humans. Like other histone variants, H2A.Z is encoded by a unique gene, resulting in a slightly divergent type of H2A with specialized functions. H2A.Z is involved in chromatin compaction by stabilizing the histone octamer within the nucleosome. It promotes gene expression through the creation of an open domain of chromatin that is more easily transcribed. H2A.Z is nonrandomly distributed throughout the genome, targeted primarily to pericentric heterochromatin, but excluded from the inactive X chromosome and the nucleolus. H2A.Z is associated with both euchromatin and facultative heterochromatin. DNA methylation can influence chromatin structure and effect gene silencing by excluding H2A.Z, and likewise, H2A.Z protects genes from DNA methylation. Thus, H2A.Z plays a role in regulating heterochromatin silencing and is involved in transcriptional control. View All» Species Reactivity:

• Chicken

• Human

• Zebrafish

• Rabbit

• Rat

• Xenopus

• Mouse
  View All» Species Reactivity Note: Human. Predicted to cross-react with zebrafish, mouse, chicken, rat, rabbit, and Xenopus based on sequence homology. View All» Control: HeLa cell lysate. View All» Quality Assurance: Western Blot Analysis: 1:1,000 dilution of this lot detected Histone H2A.Z in 10 μg of HeLa cell lysates. View All» Presentation: Purified sheep polyclonal IgG in PBS, pH 7.4 containing with 1% BSA with 0.02% sodium azide. View All» Storage Conditions: Stable for 1 years at 2-8°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap. Avoid freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P0C0S5 View All» Entrez Gene Number: NP_036544 View All» Gene Symbol:
  • H2A.z

  • H2A/z

  • H2AZ

  • MGC117173

  • H2AFZ
    View All» Alternate Names:
    • H2A histone family, member Z

    • H2AZ histone
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. Several transcript variants encoding different isoforms, have been identified for this gene. View All» UniProt Summary: FUNCTION: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. Ref.7SUBUNIT STRUCTURE:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ interacts with INCENP By similarity.SUBCELLULAR LOCATION:Nucleus. PTM: Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis By similarity.Not phosphorylated By similarity.SIMILARITY: Belongs to the histone H2A family.MOLECULAR WEIGHT: is 13413.4 Da from positions 2 - 128. Determined by ESI. Monoisotopic, not modified. Ref.8 Ref.10 Ref.11 View All» Product Name: Anti-Histone H2A.Z Antibody (09-862) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Sheep View All»
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