货号：09-864

品牌：Merck Millipore

规格：100Ug

目录价：￥5820.00

市场价格：￥4947.00

会员价格：￥4656.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-JHDM1B (KDM2B) Antibody | 09-864 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~165 kDa observed. An uncharacterized lower molecular weight band may be observed in some lysates. View All» Immunogen: KLH-conjugated linear peptide corresponding to human JHDM1B. View All» Background Information: JHDM1B (jumonji domain-containing histone demethylation protein 1B) and KDM2B. Due to the presence of a F-box motif, this protein is also known as the F-box/LRR-repeat protein 10 (FBXL 10). This protein functions as a histone demethylase for lysine 36 of histione H3 and preferentially demethylates dimethylated lysine 3 with weak or no activity for mono- and tri-methylted H3 lysine 36. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Rabbit

• Chimpanzee

• Horse

• Pig
  View All» Species Reactivity Note: Demonstrated to react with Human and Mouse. Predicted to react with Rat, Rabbit, Chimpanzee, Equine, and Porcine based on 100% sequence homology. View All» Application Notes: Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected JHDM1B in NIH/3T3 and HeLa cells. View All» Control: HeLa nuclear extract View All» Quality Assurance: Evaluated by Western Blot in HeLa nuclear extract.Western Blot Analysis: 1 µg/mL of this antibody detected JHDM1B on 10 µg of HeLa nuclear extract. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q8NHM5 View All» Entrez Gene Number: NP_115979 View All» Gene Symbol:
  • KDM2B

  • CXXC2

  • FBXL10

  • JHDM1B

  • PCCX2

  • Fbl10

  • FBL10
    View All» Alternate Names:
    • JMJD

    • lysine (K)-specific demethylase 2B

    • F-box protein FBL10

    • [Histone-H3]-lysine-36 demethylase 1B

    • JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein

    • F-box and leucine-rich repeat protein 10

    • protein containing CXXC domain 2

    • jumonji C domain-containing histone demethylase 1B

    • Jumonji domain-containing EMSY-interactor methyltransferase motif protein

    • lysine-specific demethylase 2B

    • Protein-containing CXXC domain 2

    • JmjC domain-containing histone demethylation protein 1B

    • Protein JEMMA

    • F-box/LRR-repeat protein 10

    • CXXC-type zinc finger protein 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. CATALYTIC ACTIVITY: Protein N6,N(6)-dimethyl-L-lysine + 2-oxoglutarate + O2 = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO2. Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O2 = protein L-lysine + succinate + formaldehyde + CO2. COFACTOR: Binds 1 Fe2+ ion per subunit (By similarity).SUBUNIT STRUCTURE: Directly interacts with SKP1A and CUL1 (By similarity).SUBCELLULAR LOCATION: Nucleus › nucleolus DOMAIN: The JmjC domain mediates demethylation activity (By similarity). It is also required for repression of ribosomal RNA genes.SEQUENCE SIMILARITIES: Belongs to the JHDM1 histone demethylase family.Contains 1 CXXC-type zinc finger.Contains 1 F-box domain.Contains 1 JmjC domain.Contains 4 LRR (leucine-rich) repeats.Contains 1 PHD-type zinc finger.SEQUENCE CAUTION: The sequence AAH08735.2 differs from that shown. Reason: Erroneous initiation. The sequence BAB55112.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB55301.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC11159.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-JHDM1B View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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