货号：09-871

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Elp1 Antibody | 09-871 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~150 kDa observed View All» Immunogen: KLH-conjugated linear peptide corresponding to mouse Elp1. View All» Background Information: Elongation protein 1 (Elp1), also referred to as IKAP (I-KappaB-Associated Protein) is a subunit of the RNA polymerase II elongator complex. As part of the RNA polymerase II (Pol II) holoenzyme, this protin functions as a histone acetyltransferase component involved in transcriptional elongation. Studies suggest that this protein plays a role in chromatin remodeling via acetylation of histones H3 and H4. View All» Species Reactivity:

• Mouse

• Human

• Rat

• Pig

• Rhesus Macaque

• Horse

• Chimpanzee

• Canine
  View All» Species Reactivity Note: Demonstrated to react with Mouse. Predicted to react with Human, Rat, Porcine, Rhesus Macaque, Equine, Chimpanzee, and Canine based on 100% sequence homology. View All» Application Notes: Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in IP. (Yi Zhang, Ph.D., Howard Hughes Medical Institute) View All» Control: Mouse embryonic stem cell lysate View All» Quality Assurance: Evaluated by Western Blot in mouse embryonic stem cell lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected Elp1 on 10 µg of mouse embryonic stem cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q7TT37 View All» Entrez Gene Number: NP_080355 View All» Gene Symbol:
  • Ikbkap

  • Elp1

  • Ikap
    View All» Alternate Names:
    • Elongator complex protein 1

    • ELP1

    • IkappaB kinase complex-associated protein

    • IKK complex-associated protein
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation
        View All» UniProt Summary: FUNCTION: May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (By similarity).Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4 (By similarity).SUBUNIT STRUCTURE: Interacts preferentially with MAP3K14/NIK followed by IKK-alpha and IKK-beta. Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, and two yet unidentified proteins. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with ELP3 (By similarity).SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). TISSUE SPECIFICTY: Widely expressed with highest levels in brain. DEVELOPMENTAL STAGE: Expressed at embryonic days 7, 11, 15 and 17 with the highest expression at embryonic day 11. PTM: Phosphorylated (By similarity).SEQUENCE SIMILARITIES: Belongs to the ELP1/IKA1 family.SEQUENCE CAUTION: The sequence AAL36025.1 differs from that shown. Reason: Frameshift at position 498. The sequence AAO15309.1 differs from that shown. Reason: Frameshift at several positions. View All» Product Name: Anti-Elp1 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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