货号：09-874

品牌：Merck Millipore

规格：100Ug

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SAP30 (yeast) Antibody | 09-874 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Recognizes yeast SAP30 at ~27 kDa. View All» Molecular Weight: ~27 kDa View All» Epitope: a.a. 141-157 View All» Immunogen: Immunogen was a synthetic peptide corresponding to a.a. 141-157 of yeast SAP30, conjugated to KLH. View All» Background Information: SAP30 (Sin3A-associated protein) is a widely expressed nuclear protein that is functionally conserved between human and yeast. It is a component of the multiprotein histone deacetylase complex containing the transcriptional repressor Sin3, multiple histone deacetylases (HDAC1 and HDAC2), histone binding proteins (RbAp46 and RbAp48) and other polypeptides. SAP30 can recruit the deacetylase complex to promoter DNA in a Sin3 independent manner and is involved in the recruitment of the mSin3 complex to a specific subset of N-CoR corepressor complexes. The latter function suggests a role for SAP30 in N-CoR-mediated repression. Furthermore, SAP30 may be involved in imparting target specificity to the deacetylase complex. View All» Species Reactivity: Yeast (S. cerevisiae) View All» Species Reactivity Note: Yeast (Saccharomyces cerevisiae). Not tested in other species. View All» Control: Yeast extract View All» Quality Assurance: Western Blot Analysis: 1 μg/ml of this antibody detected SAP30 in a yeast extract. View All» Presentation: Protein A purified IgG in 0.1M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% NaN3. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of shipment. View All» UniProt Number: P38429 View All» Entrez Gene Number: NM_003864.3 View All» Gene Symbol: SAP30 View All» Alternate Names:

• Sin3 corepressor complex subunit SAP30

• Sin3-associated polypeptide, 30 kDa

• Sin3-associated polypeptide, 30kDa

• Sin3A-associated protein, 30kDa

• histone deacetylase complex subunit SAP30
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq] View All» UniProt Summary: FUNCTION: Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.SUBUNIT:Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, UME1 and UME6.SUBCELLULAR LOCATION: Nucleus.MISCELLANEOUS: Present with 704 molecules/cell in log phase SD medium.SIMILARITY: Belongs to the SAP30 family. View All» Product Name: Anti-SAP30 (yeast) Antibody | 09-874 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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