金山科研平台，产品价格货期咨询微信：jinshanbio Source:E. coli-derived Accession #:Q62386 (IL-17A) & AAM77568 (IL-17F) N-terminal Sequence Analysis:Thr22 (IL-17A) &Met (IL-17F) Structure:Disulfide-linked heterodimer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:14.9 kDa (IL-17A) & 15.5 kDa (IL-17F), reducing conditions Activity:Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells. Yao, Z. et al. (1995) Immunity 3:811.The ED₅₀ for this effect is typically 0.075 - 0.375 µg/mL. Molecule Information: IL-17A/F Heterodimer Long Name: Interleukin 17 A/F Background: IL-17 Ligands The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.