货号：09-882

品牌：Merck Millipore

规格：100UL

目录价：￥4439.00

市场价格：￥3773.15

会员价格：￥3551.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ALKBH3 Antibody | 09-882 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the N-terminus of ALKBH3. View All» Molecular Weight: ~35 kDa observed View All» Epitope: N-terminus View All» Immunogen: Histidine-tagged-recombinant protein corresponding to the the N-terminus of human ALKBH3. View All» Background Information: ABH3 is a member of the Fe(II)/2OG-dependent dioxygenase superfamily, which couples substrate oxidation by converting 2-oxoglutarate (2OG) into succinate and CO2. In humans, ABH3 plays a critical role in alkylated DNA/RNA damage repair and in cancer therapy. While ABH3 may repair alkylated RNA, it demonstrates greater preference for the repair of single- over double-stranded alkylated DNA through oxidative demethylation of 1-methyladenine and 3-methylcytosine. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. Other homologies Orangutan 98% and Rhesus Monkey 97% sequence homology. View All» Application Notes: Western Blot Analysis: A representative lot from an independent laboratory detected ALKBH3 in PC-3 and LNCap whole cell extract. (Dango, S., et al. (2011). Mol Cell. {Epub ahead of print.}) View All» Control: Human prostate tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human prostate tissue lysate.Western Blot Analysis: A 1:5,000 dilution of this antibody detected ALKBH3 in human prostate tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q96Q83 View All» Entrez Gene Number: NP_631917 View All» Gene Symbol:

• ALKBH3

• ABH3

• DEPC1
  View All» Alternate Names:
  • Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

  • Alkylated DNA repair protein alkB homolog 3

  • DEPC-1

  • Prostate cancer antigen 1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine. View All» UniProt Summary: FUNCTION: Dioxygenase that repairs alkylated DNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Has a strong preference for single-stranded DNA. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron.COFACTOR: Binds 1 Fe2+ ion per subunit.ENZYME REGULATION: Activated by ascorbate.SUBCELLULAR LOCATION: Cytoplasm. Nucleus.TISSUE SPECIFICITY: Ubiquitous. Detected in heart, pancreas, skeletal muscle, thymus, testis, ovary, spleen, prostate, small intestine, peripheral blood leukocytes, urinary bladder and colon. View All» Product Name: Anti-ALKBH3 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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