金山科研平台，产品价格货期咨询微信：jinshanbio Source:Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Thr32-His266 Accession #:O94907 N-terminal Sequence Analysis:Thr32 Purity:>95%, by SDS-PAGE with silver staining. Endotoxin Level: Predicted Molecular Mass:25.8 kDa SDS-PAGE:33-38 kDa, reducing conditions Activity:Measured by its ability to inhibit Wnt-3a-induced alkaline phosphatase production by MC3T3‑E1 mouse preosteoblast cells.The ED₅₀ for this effect is typically 0.03-0.15µg/mL in the presence of 10 ng/mL of Recombinant Mouse Wnt‑3a (Catalog# 1324-WN). Molecule Information: Dkk-1 Long Name: Dickkopf-1 Entrez Gene IDs: 22943 (Human); 13380 (Mouse) Background: Dkk Family Members of the dickkopf-related protein family (Dkk-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. Dkk-3 and -4 also have one prokineticin domain. Dkk-1, -2, and -4 function as antagonists of canonical Wnt signaling by binding to LRP5/6, preventing interaction of LRP5/6 with Wnt-Frizzled complexes. Dkk-1, -2, and -4 also bind cell surface Kremen-1 or -2 and promote the internalization of LRP5/6. Antagonistic activity of Dkk-3 has not been demonstrated. Dkk proteins have distinct patterns of expression in adult and embryonic tissues and have a wide range of effects on tissue development and morphogenesis. The Dkk family also includes Soggy, which is homologous to Dkk-3 but not to the other family members. Soggy has not been shown to inhibit Wnt signaling, and its role in the pathway is unclear.