R&D Systems代理5614-NL-050 Recombinant Human Olfactomedin-2/Noelin-2 Protein, CF (50 UG)-试剂-金山科研平台

R&D Systems代理5614-NL-050 Recombinant Human Olfactomedin-2/Noelin-2 Protein, CF (50 UG)

2025-06-28

货号：5614-NL-050

品牌：R&D Systems

规格：50ug

目录价：￥4490.00

市场价格：￥3592.00

会员价格：￥3592.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived, Gln21-Pro454, with a C-terminal 6-His tag Accession #:NP_477512 N-terminal Sequence Analysis:No results obtained: Gln21 predicted Purity:>90%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:50 kDa SDS-PAGE:55-75 kDa, reducing conditions Activity:Measured by the ability of the immobilized protein to support the adhesion of HEK293T human embryonic kidney cells.

When 5 x 10⁴ cells per well are added to human Olfactomedin-2 coated plates (1µg/mL, 100µL/well), approximately 50% - 75% will adhere after 1 hour at 37 °C.

Optimal dilutions should be determined by each laboratory for each application.

Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: Olfactomedin-2/Noelin-2 Aliases: NOE2; Noelin-2; OlfC; OLFM2; OM2 Entrez Gene IDs: 93145 (Human); 244723 (Mouse); 313783 (Rat) Background: Olfactomedin-2 Olfactomedin-2 (OLFM2, OM2), also called OlfC or neuronal olfactomedin-related endoplasmic reticulum-localized-2 (Noelin-2) is a 50 kDa (predicted), secreted member of the olfactomedin/noelin family of proteins. Since Noelin-2 has also been used to designate an alternately spliced form of Noelin-1, Olfactomedin-2 is the less ambiguous name. Olfactomedin domain-containing proteins are often found in neural tissues. Human Olfactomedin-2 expressed sequence tags have mainly been found in the brain and eye, and RNA in the cerebellum. In zebrafish, Olfactomedin-2 expression is developmentally regulated and, like Noelin-1, may play a role in neural crest cell differentiation. The human Olfactomedin-2 cDNA encodes a 20 amino acid (aa) signal sequence and a 454 mature protein that contains two coiled-coil regions (aa 58-85 and 136-193) and an Olfactomedin domain (aa 194-446). Mature human Olfactomedin-2 shares 98% aa identity with rat, bovine and equine, 97% with mouse and canine, 81% with Xenopus, and 77% with zebrafish Olfactomedin-2. No alternate splice variants have been reported for Olfactomedin-2. Polymorphisms of human Olfactomedin-2, with or without additional polymorphisms in optineurin (OPTN), have been associated with a small fraction of high intraocular pressure or open-angle glaucoma cases in Japanese patients. The family member myocilin shows stronger association with these ocular disorders, and either myocilin or Noelin-1 might heterodimerize with Olfactomedin-2. Evidence suggests that Olfactomedin-2 has evolved from Noelin-1 gene duplication, and myocilin from Olfactomedin-2 gene duplication.

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