金山科研平台，产品价格货期咨询微信：jinshanbio Source:Spodoptera frugiperda, Sf 21 (baculovirus)-derived Accession #:Q4FK69 N-terminal Sequence Analysis:Phe14 Structure:Disulfide-linked homodimer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:64.7 kDa (monomer) SDS-PAGE:70-80 kDa, reducing conditions Activity:Measured by its ability to inhibit IL-1 alpha -dependent proliferation in D10.G4.1 mouse helper T cells. Symons, J.A. etal. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. etal. (eds): IRL Press. 272.Approximately 2-8µg/mL of IL-1RII will inhibit 50% of the biological response due to 50 pg/mL of recombinant mouse IL-1 alpha. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: IL-1 RII Long Name: Interleukin 1 Receptor II Aliases: CD121b; IL-1 R beta; IL1R2 Entrez Gene IDs: 7850 (Human); 16178 (Mouse) Background: IL-1 RII

IL-1 RII has a short cytoplasmic domain and does not transduce IL-1 signals. In addition to the membrane-bound form of IL-1 RII, a naturally-occurring soluble form of IL-1 RII has been described. It has been suggested that the Type II receptor, either as the membrane-bound or as the soluble form, serves as a decoy for IL-1 and inhibits IL-1 action by blocking the binding of IL-1 to the signaling Type I receptor complex. Recombinant IL-1 soluble receptor type II is a potent antagonist of IL-1 action.