金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Gln27-Leu559, with a C-terminal 10-His tag Accession #:O00748 N-terminal Sequence Analysis:No results obtained: Gln27 predicted Structure:Monomer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin Level: Predicted Molecular Mass:60 kDa SDS-PAGE:63 kDa, reducing conditions Activity:Measured by its ability to hydrolyze p-nitrophenylacetate.The specific activity is >30,000 pmol/min/µg, measured under the described conditions. Formulation:Supplied as a 0.2 µm filtered solution in Sodium Acetate, NaCl and Glycerol.See Certificate of Analysis for details. Molecule Information: Carboxylesterase 2/CES2 Aliases: CE-2; CES2; PCE-2 Entrez Gene IDs: 8824 (Human); 234671 (Mouse); 171118 (Rat) Background: Carboxylesterase 2

Carboxylesterase 2 (CES2) is a member of a large family of carboxylesterases that are responsible for the hydrolysis of ester and amide bonds. They have broad substrate specificity ranging from small molecule esters such as phenylester to long-chain fatty acid esters and thioesters. Carboxylesterases play a major role as determinants of pharmacokinetic behavior for most therapeutic agents containing an ester, participating in the detoxification of drugs such as cocaine and heroin in serum and liver. They can also detoxify organophosphate and carbamate analogues used in agrochemicals or chemical nerve agents, such as malathion, sarin, tabun, and VX.

Carboxylesterases can also perform transesterification, a reaction important for cholesterol homeostasis. Carboxylesterase deficiency may be associated with non-Hodgkin lymphoma or B-cell lymphocytic leukemia. CES2, also known as acylcarnitine hydrolase M1, shares the serine hydrolase fold observed in other esterases. CES2 possesses an endoplasmic reticulum retention signal (HREL) at its C-terminus.