货号：12-002

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Otubain 1 View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 20 µg View All» Product Overview: Histidine-tagged full length recombinant Otubain 1 View All» Background Information: Otubain 1 is classified as belonging to a group of deubiquitinating cysteine proteases known as the OTU family. This family functions as regulators for highly aberrant physiological processes. As a ubiquitin-specific protease, studies for Otubain 1 have recognized it mainly for its function in regulating T-cell energy through the process of binding Grail and causing it subsequent degradation. The means for regulating Otubain 1 expression are still unknown. View All» Key Applications: Activity Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. View All» UniProt Summary: Hydrolase that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a nuch lower preference compared to 'Lys-48'-linked ubiquitin. View All» Species: Human View All» Molecular Weight: 37 kDa View All» Brand Family: Upstate View All» Source: Expressed in E. Coli View All» Storage Conditions: 6 months at -80°C View All» Gene Symbol:

• OTUB1

• OTB1

• OTU1
  View All» Product Name: Otubain 1 View All» Concentration: 0.5 µg/µL View All» UniProt Number: Q96FW1 View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Entrez Gene Number: NP_060140 View All» Purification Method: Affinity chromatography View All»
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