R&D Systems代理566-NNS-025 Recombinant Rat Neuropilin-1 Fc Chimera (NS0-expressed), CF (25 UG)

2025-06-27

货号:566-NNS-025

品牌:R&D Systems

规格:25ug

目录价:¥4490.00

市场价格:¥3592.00

会员价格:¥3592.00

  • 到货时间:3~4周

    金山科研平台,产品价格货期咨询微信:jinshanbio Source:Mouse myeloma cell line, NS0-derived Accession #:Q9QWJ9 N-terminal Sequence Analysis:Phe22 Structure:Disulfide-linked homodimer Purity:>90%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:119 kDa (monomer) SDS-PAGE:130-150 kDa, reducing conditions Activity:Measured by its binding ability in a functional ELISA.Immobilized rrNpn-1/Fc Chimera at 2µg/mL (100µL/well) can bind rhVEGF165 in the presence of 2 µg/mL of heparin with an apparent KD < 1 nM. Formulation:Lyophilized from a 0.2 µm filtered solution in Citrate Phosphate and NaCl.See Certificate of Analysis for details. Molecule Information: Neuropilin-1 Aliases: BDCA-4; CD304; NRP1 Entrez Gene IDs: 8829 (Human); 18186 (Mouse); 246331 (Rat) Background: Neuropilins Neuropilin-1 (Npn-1, previously known as neuropilin) and Neuropilin-2 (previously known as Npn-1-related molecule) are type I transmembrane proteins that bind distinct members of the class III secreted semaphorin subfamily that are implicated in repulsive axon guidance. Neuropilin extracellular domains contain two CUB (complement-binding) domains, two domains with homology to coagulation factors V and VIII, and a MAM (meprin) domain. In the absence of ligands, neuropilins can form homo- and hetero-oligomers via their MAM domains. Expression in developing neurons of the central and peripheral nervous systems is somewhat overlapping but distinct. Npn-1 and Npn-2 are also receptors for VEGF165 on endothelial and tumor cells.

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