金山科研平台，产品价格货期咨询微信：jinshanbio Source:E. coli-derived, Met1-Gln266, with a C-terminal 6-His tag Accession #:P15428 N-terminal Sequence Analysis:Met1 Structure:Noncovalently-linked homodimer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin Level: Predicted Molecular Mass:30kDa SDS-PAGE:28 kDa, reducing conditions Activity:Measure by the production of NADH during the oxidation of PGF2 alpha.The specific activity is >1,500 pmol/min/µg, as measured under the described conditions. Formulation:Supplied as a 0.2 µm filtered solution in HEPES, NaCl, DTT and Glycerol.See Certificate of Analysis for details. Molecule Information: 15-PGDH/HPGD Long Name: 15-Hydroxyprostaglandin Dehydrogenase Aliases: HPGD; PGDH1; SDR36C1 Entrez Gene IDs: 3248 (Human); 15446 (Mouse); 79242 (Rat) Background: 15-PGDH HPGD, or 15-hydroxyprostaglandin dehydrogenase, is a NAD⁺-linked dehydrogenase that oxidizes the hydroxyl group at position 15 of prostaglandins to a ketone, resulting in a loss of biological activity. HPGD is a major enzyme for the catabolism of prostaglandins. The enzyme is a member of the short-chain alcohol dehydrogenase family of enzymes. HPGD is a cytosolic enzyme expressed in most tissues, with highest expression levels in placenta, lung, and kidney. It is inhibited by aspirin and nonsteroidal anti-inflammatory drugs. Defects in HPGD are a cause of hypertrophic osteoarthropathy.