金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Lys33-Pro528, with a C-terminal 6-His tag (Asp526Asn) Accession #:AAN70994 N-terminal Sequence Analysis:Lys33 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:49.1 kDa SDS-PAGE:60 kDa, reducing conditions Activity:Measured by the ability of the immobilized protein to support the adhesion of BUD‑8 human fibroblast cells.When 3 x 10⁴ cells/well are added to rhCDSN coated plates (10 µg/mL, 100 µL/well), approximately 50 - 80% will adhere after 1 hour at 37 °C. Optimal dilutions should be determined by each laboratory for each application. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: Corneodesmosin Aliases: CDSN; D6S586E; HTSS Entrez Gene IDs: 1041 (Human); 386463 (Mouse) Background: Corneodesmosin Corneodesmosin (CDSN) is a highly polymorphic glycoprotein that is secreted by differentiated keratinocytes and by inner root sheath cells of hair follicles. Corneodesmosin forms oligomers and associates homophilically to strengthen the adhesion between corneocytes. Sequential proteolysis of Corneodesmosin diminishes its ability to mediate adhesion, and this is a prerequisite for normal desquamation of the skin. Defects in the synthesis or proteolysis of Corneodesmosin are associated with the development of psoriasis and hypotrichosis of the scalp.