R&D Systems代理576-LS-100 Recombinant Mouse L-Selectin/CD62L Fc Chimera Protein, CF (100 UG)-试剂-金山科研平台

R&D Systems代理576-LS-100 Recombinant Mouse L-Selectin/CD62L Fc Chimera Protein, CF (100 UG)

2025-06-27

货号：576-LS-100

品牌：R&D Systems

规格：100ug

目录价：￥4490.00

市场价格：￥3592.00

会员价格：￥3592.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived Accession #:Q3UV83 N-terminal Sequence Analysis:Trp39 Structure:Disulfide-linked homodimer Purity:>90%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:60.5 kDa (monomer) SDS-PAGE:150 kDa, reducing conditions Activity:Measured by the ability of the immobilized protein to support the adhesion of LS180 human colorectal adenocarcinoma cells.

When5 x 10⁴ cells/well are added to Recombinant Mouse L‑Selectin/CD62L FcChimera coated plates, adhesion is induced in a dose dependent manner after a1hour incubation at 37 °C. The ED₅₀ for this effect is typically0.3 -1.2µg/mL.

Optimal dilutions should be determined by each laboratory for each application.

Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: L-Selectin/CD62L Aliases: CD62L; hLHRc; LAM1; LECAM1; Leu-8; LNHR; LSEL; LYAM1; Lyam-1; PLNHR; SELL; TQ1 Entrez Gene IDs: 6402 (Human); 20343 (Mouse); 29259 (Rat) Background: Selectins The Selectin family is comprised of three members, E-Selectin, L-Selectin, and P-Selectin. E-Selectin [endothelial leukocyte adhesion molecule-1 (ELAM-1), CD62E] is transiently expressed on vascular endothelial cells in response to IL-1 beta and TNF-alpha. The human and rat proteins share approximately 67% amino acid sequence identity. The mouse and rat proteins share approximately 78% amino acid sequence identity. L-Selectin (Leukocyte Selectin, LAM-1, LECAM-1, LECCAM-1, TQ1, Leu-8, MEL-14 antigen, DREG, lymph node homing receptor, CD62L) is expressed constitutively on a wide variety of leukocytes. Two forms of L-Selectin have been reported, apparently arising as a result of post-translational modifications. Human and mouse L-Selectin share 76% amino acid sequence identity. Human P-Selectin (GMP-140, LECAM-3, PADGEM, CD62P) is expressed by activated platelets and endothelial cells. The extracellular domains of human and mouse P-Selectin share approximately 73% amino acid sequence identity.

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