货号：12-350

品牌：Merck Millipore

规格：1EA

目录价：￥7490.77

市场价格：￥6367.15

会员价格：￥5992.62

金山科研平台，产品价格货期咨询微信：jinshanbio Description: GST View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Key Applications: Western Blotting View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. View All» UniProt Summary: FUNCTION: SwissProt: P08263 # Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.SIZE: 222 amino acids; 25631 Da SUBUNIT: Homodimer or heterodimer of GSTA1 and GSTA2.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Liver.DOMAIN: SwissProt: P08263 The C-terminal domain may form a component of the hydrophobic substrate-binding site, but in contrast appears not to be directly involved in GSH binding and is not absolutely essential for catalytic activity.SIMILARITY: Belongs to the GST superfamily. Alpha family. View All» Brand Family: Upstate View All» Presentation: 50mM Tris-HCl, pH 8.0, 5mM 2-mercaptoethanol View All» UniProt Number: P08263 View All» Storage Conditions: 1 year at -70°C View All» Gene Symbol:

• GSTA1

• GST2

• H-A

• GTH1

• GSTA1-1

• MGC131939

• GST-epsilon
  View All» Product Name: GST View All» Entrez Gene Number: NM_145740.2 View All»
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