货号：12-355

品牌：Merck Millipore

规格：1EA

目录价：￥2904.10

市场价格：￥2468.49

会员价格：￥2323.28

金山科研平台，产品价格货期咨询微信：jinshanbio Description: SAMS Peptide View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Key Applications: Kinase Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. View All» UniProt Summary: FUNCTION: SwissProt: Q00266 # Catalyzes the formation of S-adenosylmethionine from methionine and ATP.COFACTOR: Binds 2 divalent ions per subunit. Magnesium or cobalt (By similarity). & Binds 1 potassium ion per subunit (By similarity).SIZE: 395 amino acids; 43648 Da SUBUNIT: Homotetramer (MAT-I) or homodimer (MAT-III).TISSUE SPECIFICITY: Expressed in liver.DISEASE: SwissProt: Q00266 # Defects in MAT1A are a cause of a form of hypermethioninemia [MIM:250850]; also called MAT I/III deficiency. The disease is characterized by fetid breath and dimethylsulfide excretion. Most mutations are transmitted in an autosomal recessive manner, but autosomal dominant inheritance has also been observed. The clinical consequences of hypermethioninemia are poorly understood. In some individuals, hypermethioninemia is apparently benign; in others, association of neurological problems with null mutations has been observed.SIMILARITY: SwissProt: Q00266 ## Belongs to the AdoMet synthetase family. View All» Quality Assurance: Routinely evaluated by Peptide Phosphorylation Assay. SAMS Peptide was phosphorylated by AMP activated enzyme in the presence and absence of AMP. View All» Brand Family: Upstate View All» Presentation: sterile distilled water View All» Protein Target: AMPK (α1, β1, γ1) View All» UniProt Number: Q00266 View All» Target Sub-Family: CAMK View All» Storage Conditions: 2 years at -20°C View All» Gene Symbol:

• MAT1A

• SAMS

• AMS1

• MAT

• MATA1

• SAMS1

• MAT-I/III
  View All» Product Name: SAMS Peptide View All» Entrez Gene Number: NM_000429.2 View All»
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