金山科研平台，产品价格货期咨询微信：jinshanbio Source:E. coli-derived, Gly81-Ala210 Accession #:XP_538958.2 N-terminal Sequence Analysis:Gly81 Structure:Disulfide-linked homodimer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:15.2 kDa (monomer) SDS-PAGE:14 kDa, reducing conditions Activity:Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells. Yao, Z. et al. (1995) Immunity 3:811.The ED₅₀ for this effect is typically 0.3-1.5 ng/mL. Molecule Information: IL-17/IL-17A Long Name: Interleukin 17 Aliases: CTLA-8; IL17A Entrez Gene IDs: 3605 (Human); 16171 (Mouse); 301289 (Rat); 481837 (Canine) Background: IL-17 Ligands The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.