金山科研平台，产品价格货期咨询微信：jinshanbio Source:E. coli-derived, Ser2-Ser501, with an N-terminal Met and 6-His tag Accession #:P00352 N-terminal Sequence Analysis:Ser2 Structure:Noncovalently-linked homotetramer Purity:>90%, by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin Level: Predicted Molecular Mass:56 kDa SDS-PAGE:57 kDa, reducing conditions Activity:Measured by its ability to produce NADH during the oxidation of propionaldehyde.The specific activity is >150 pmol/min/µg, as measured under the described conditions. Formulation:Supplied as a 0.2 µm filtered solution in Tris, NaCl, Glycerol and DTT.See Certificate of Analysis for details. Molecule Information: Aldehyde Dehydrogenase 1-A1/ALDH1A1 Aliases: ALDC; ALDH1A1; ALDH-E1; PUMB1; RALDH1 Entrez Gene IDs: 216 (Human) Background: Aldehyde Dehydrogenase 1-A1 Aldehyde dehydrogenases (ALDHs) are NAD(P)⁺-dependent enzymes that detoxify aldehydes by oxidizing them to carboxylic acids. Nineteen ALDHs are present in humans, expressed in a variety of organelles and having different substrate preferences. ALDH1A1 is a cytosolic enzyme that preferentially oxidizes retinaldehyde to retinoic acid. ALDH1A1 is expressed in the epithelium of many organs, including brain, liver, testis, eye lens and cornea. ALDH1A1 is highly expressed in brain dopaminergic neurons, where it produces the retinoic acid required for their differentiation and development. The retinoic acid produced by ALDH1A1 is also important for the differentiation of hematopoietic stem cells. ALDH1A1 is a major enzyme in the oxidation of acetaldehyde, a toxic metabolite of ethanol.