R&D Systems代理5926-S3-025/CF Recombinant Mouse Semaphorin 3A Fc Chimera Protein, CF (25 UG)-试剂-金山科研平台

R&D Systems代理5926-S3-025/CF Recombinant Mouse Semaphorin 3A Fc Chimera Protein, CF (25 UG)

2025-06-27

货号：5926-S3-025/CF

品牌：R&D Systems

规格：25ug

目录价：￥4490.00

市场价格：￥3592.00

会员价格：￥3592.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived Accession #:O08665 N-terminal Sequence Analysis:Asn21 Structure:Disulfide-linked homodimer Purity:>90%, by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin Level: Predicted Molecular Mass:110.1 kDa (monomer) SDS-PAGE:115-120 kDa, reducing conditions Activity:Measured by its ability to cause collapse of chick embryonic dorsal root ganglia (DRG) neuron growth cones.

The ED₅₀ for this effect is typically 20 - 60 ng/mL in the presence 10 ng/mL recombinant human beta ‑NGF.

Molecule Information: Semaphorin 3A Aliases: Sema3A Entrez Gene IDs: 10371 (Human) Background: Semaphorins The Semaphorins make up the largest family of axon guidance cues yet described. Semaphorins are divided into 8 classes (classes 3-7 found in vertebrates). Class 3 Semaphorins are secreted, classes 4 through 6 are transmembrane proteins, and class 7 are membrane associated via glycosylphosphatidylinositol (GPI) linkage. They are characterized structurally by a conserved ~400 amino acid sema domain. They are classically described as collapsing factors and mediators of axon repulsion, although they may also act as context-dependent chemoattractants. Semaphorins have been shown to have roles in cardiovascular development and in the regulation of immune cell antigen presentation. Receptors or receptor complexes that mediate semaphorin signaling include proteins of the Neuropilin and Plexin families.

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