金山科研平台，产品价格货期咨询微信：jinshanbio Source:E. coli-derived, Pro25-Ser146, with and without an N-terminal Met Accession #:Q9ES17.1 N-terminal Sequence Analysis:Pro25 & Met Purity:>97%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:14.4 kDa Activity:Measured in a cell proliferation assay using N1186 human T cells. Parrish-Novak, J. et al. (2000) Nature 408:57.The ED₅₀ for this effect is typically 4 - 30 ng/mL. Molecule Information: IL-21 Long Name: Interleukin 21 Entrez Gene IDs: 59067 (Human); 60505 (Mouse); 365769 (Rat); 442935 (Canine); 100344172 (Rabbit) Background: IL-21 View IL-21 IHC images.

Interleukin-21 (IL-21) and its receptor appear to play important roles in the regulation of the immune system. IL-21 is most closely related to IL-2, IL-4 and IL-15. The IL-21 Receptor (IL-21 R), also called NILR (novel interleukin receptor), is a type I cytokine receptor with 4 conserved cysteine residues and an extracellular WSXWS motif. It is most closely related to IL-2 R beta and IL-4 R alpha.

Mouse IL-21 is a 146 amino acid (aa) residue protein with a 24 aa signal peptide. Mouse and human IL-21 share 57% amino acid identity. IL-21 is expressed by activated T cells. Although not fully elucidated, the IL-2 R gamma (gamma c) chain appears to play a role in IL-21 R signaling. The IL-21/IL-21 R interaction appear to play important roles in B and T cell proliferation after antigen stimulation and NK cell maturation.