R&D Systems代理5969-GH-010 Recombinant Human Cytosolic beta-Glucosidase/GBA3, CF (10 UG)

2025-06-27

货号:5969-GH-010

品牌:R&D Systems

规格:10ug

目录价:¥4490.00

市场价格:¥3592.00

会员价格:¥3592.00

  • 到货时间:3~4周

    金山科研平台,产品价格货期咨询微信:jinshanbio Source:Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Thr13-Leu469 with a C-terminal 6-His tag Accession #:Q9H227 N-terminal Sequence Analysis:Thr13 & Pro124 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin Level: Predicted Molecular Mass:53 kDa & 41 kDa SDS-PAGE:54 kDa, reducing conditions Activity:Measured by its ability to hydrolyze 4-methylumbelliferyl-beta -D-glucopyranoside.The specific activity is >1,500 pmol/min/µg, as measured under the described conditions. Formulation:Supplied as a 0.2 µm filtered solution in Tris, NaCl, DTT and Glycerol.See Certificate of Analysis for details. Molecule Information: Cytosolic beta-Glucosidase/GBA3 Aliases: CBGL1; GBA3; GLUC; KLrP Entrez Gene IDs: 57733 (Human); 289687 (Rat) Background: Cytosolic beta-Glucosidase

    View GBA3 IHC images. There are three beta-glucosidases (GBA) in human genome. GBA1 endodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glucosylceramide. GBA2 encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides. GBA3 is a cytosolic beta-glucosidase and is predominantly expressed in liver. GBA3 efficiently hydrolyzes beta-D-glucoside and beta-D-galactoside, but not any known physiological beta-glycoside, suggesting that it may be involved in detoxification of plant glycosides. GBA3 also has significant neutral glycosylceramidase activity, suggesting that it may be involved in a nonlysosomal catabolic pathway of glucosylceramide metabolism. At the protein level, GBA3 shows significant homology (>40%) with Klotho protein that is known for its association with aging process.

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