货号:12-533
品牌:Merck Millipore
规格:1EA
目录价:¥3319.79
市场价格:¥2821.82
会员价格:¥2655.83
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Description:
GSM (GSK3 substrate peptide)
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Trade Name:
Upstate (Millipore)
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Qty/Pk:
1 mg
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Product Overview:
Synthetic peptide (RRRPASVPPSPSLS RHS(pS)HQRR) based on muscle glycogen synthase 1, where (pS) corresponds to phosphorylated serine.
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Key Applications:
Kinase Assay
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Application Notes:
Kinase Assay: Substrate for GSK3α, active (Catalog # 14-492), GSK3β, active (Catalog # 14-306), GSK3β, active, rat (Catalog # 14-538).
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
Glycogen synthase kinase 3-alpha (GSK3A; EC {2.7.1.37}) is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase (see GYS1, {138570}) and transcription factors (e.g., JUN, {165160}). It also plays a role in the WNT ({164820}) and PI3K (see PIK3CG, {601232}) signaling pathways (see review by {1:Ali et al. (2001)}).[supplied by OMIM]
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UniProt Summary:
FUNCTION: SwissProt: P49840 # Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN (By similarity).SIZE: 483 amino acids; 50981 Da SUBUNIT: Monomer (By similarity).SIMILARITY: SwissProt: P49840 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. & Contains 1 protein kinase domain.
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Molecular Weight:
Molecular weight: 2673 Daltons.
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Quality Assurance:
Routinely evaluated as a substrate for GSK3β (Catalog # 14-306).
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Brand Family:
Upstate
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Presentation:
1 mg of GSM lyophilized from 1 mL sterile, distilled water. Lyophilized powder.
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Protein Target:
GSK3
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UniProt Number:
P49840
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Target Sub-Family:
CMGC
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Storage Conditions:
Lyophilized: 2 years at -20°C. Rehydrated: 6 months at -20°C
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Gene Symbol:
-
GSK3A
-
DKFZp686D0638
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Product Name:
GSM (GSK3 substrate peptide)
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Entrez Gene Number:
NM_019884.2
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