金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived Accession #:Q53EP8 N-terminal Sequence Analysis:Gly24 Structure:Disulfide-linked homodimer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:50.5 kDa (monomer) SDS-PAGE:75-85 kDa, reducing conditions Activity:Measured by its ability to inhibit IL-4-dependent proliferation of TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323.The ED₅₀ for this effect is typically 10-40ng/mL in the presence of 0.2ng/mL recombinanthumanIL-4. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: IL-4 R alpha Long Name: Interleukin 4 Receptor alpha Aliases: CD124; IL4R Entrez Gene IDs: 3566 (Human); 16190 (Mouse) Background: IL-4 Receptor Two types of IL-4 receptor complexes have been described. The typeI IL-4 receptor complex is composed of a high-affinity IL-4-binding subunit (referred to as IL-4 R or IL-4 R alpha) and the common gamma chain that does not bind IL-4 by itself. The type II IL-4 receptor complex is composed of IL-4 R and IL-13 R alpha 1. Besides IL-4 signals, the type II IL-4 receptor complex can also transduce IL-13 signals. In the type II complex, IL-4 R subunit binds only IL-4 and not IL-13. Similarly, the IL-13 R alpha 1 subunit binds only IL-13 and not IL-4.