R&D Systems代理6057-NG-025/CF Recombinant Human Noggin Protein, CF (25 UG)-试剂-金山科研平台

R&D Systems代理6057-NG-025/CF Recombinant Human Noggin Protein, CF (25 UG)

2025-06-27

货号：6057-NG-025/CF

品牌：R&D Systems

规格：25ug

目录价：￥4350.00

市场价格：￥3480.00

会员价格：￥3480.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Gln28-Cys232 Accession #:Q13253 N-terminal Sequence Analysis:No results obtained: Gln28 predicted Structure:Disulfide-linked homodimer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:23 kDa (monomer) SDS-PAGE:30-33 kDa, reducing conditions Activity:Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells.The ED₅₀ for this effect is typically 0.04‑0.2 µg/mL in the presence of50 ng/mL of Recombinant Human BMP‑4 (Catalog# 314-BP). Molecule Information: Noggin Aliases: NOG; SYM1; SYNS1 Entrez Gene IDs: 9241 (Human); 18121 (Mouse) Background: Noggin

View Noggin IHC images. Noggin was originally identified based on its dorsalizing activity in Xenopus embryos. It was subsequently found to be a BMP binding protein that antagonizes BMP bioactivities. Mammalian Noggins were subsequently identified and cloned from human, mouse, and rat cDNA libraries. Mature mouse Noggin shares 99% and 83% amino acid sequence identity with human and Xenopus Noggin, respectively. Noggin has a complex pattern of expression during embryogenesis. In the adult, Noggin is expressed in the central nervous system and in several adult peripheral tissues such as lung, skeletal muscle, and skin.

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