R&D Systems代理6075-SM-050 Recombinant Mouse SMOC-2 Protein, CF (50 UG)-试剂-金山科研平台

R&D Systems代理6075-SM-050 Recombinant Mouse SMOC-2 Protein, CF (50 UG)

2025-06-28

货号：6075-SM-050

品牌：R&D Systems

规格：50ug

目录价：￥4490.00

市场价格：￥3592.00

会员价格：￥3592.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Leu30-Gly447, with a C-terminal 6-His tag Accession #:AAH19527 N-terminal Sequence Analysis:Leu30 Purity:>90%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:47.6 kDa SDS-PAGE:58-61 kDa, reducing conditions Activity:Measured by the ability of the immobilized protein to support the adhesion of A431 human epithelial carcinoma cells.

When 5 x 10⁴ cells/well are added to rmSMOC-2 coated plates, cell adhesion is enhanced in a dose dependent manner after 75 minutes at 37 °C. The ED₅₀ for this effect is typically 0.2-0.8 µg/mL.

Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: SMOC-2 Long Name: Secreted Modular Calcium-binding Protein 2 Aliases: MST117; MSTP117; MSTP140; SMAP2 Entrez Gene IDs: 64094 (Human); 64074 (Mouse); 292401 (Rat) Background: SMOC-2 SMOC-2 (secreted, or SPARC-related, modular calcium-binding protein 2), previously called SMAP2 (smooth muscle-associated protein 2), is a 55 kDa glycoprotein that is a member of the SPARC family of matricellular proteins. The human SMOC-2 cDNA encodes 446 amino acids (aa), including a 21 aa signal sequence, a Kazal-like domain (aa 40-84), two thyroglobulin type-1 segments (aa 87-153 and 213-281) and two EF-hand sequences (aa 347-382 and 384-419). Of three splice variants, one shows a 13 aa substitution for aa 442-446, another shows an 11 aa insertion after Thr170, and a third contains both of these variations. Mature human SMOC-2 shares 95%, 95% and 94% aa identity with mouse, rat and canine SMOC-2, respectively. SMOC-2 is widely expressed in the extracellular matrix and appears to have adhesion-related functions. Recombinant bacterially produced human SMOC-1 and SMOC-2 can bind the acute phase protein, C-reactive protein, and the adhesion proteins, fibulin and vitronectin, while keratinocyte SMOC-2 binds integrins alpha V beta 1 and alpha V beta 6. SMOC-2 promotes cell cycle progression by signaling through the integrin-linked kinase (ILK) to upregulate cyclin-D1. When expressed in the endothelial extracellular matrix, it potentiates growth factor-induced angiogenesis. SMOC-2 expression is upregulated during neointima formation, promoting proliferation and migration of vascular smooth muscle. In the skin, it promotes keratinocyte attachment and migration. Since Kazal and thyroglobulin domains are often found in protease inhibitors, SMOC-2 is also proposed to inhibit proteases in the lung and artery.

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