金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived, Met1-Leu602, with a C-terminal 6-His tag Accession #:P06276 N-terminal Sequence Analysis:Glu29 Structure:Monomer and disulfide-linked homodimers Purity:>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 µg per lane. Endotoxin Level: Predicted Molecular Mass:66 kDa SDS-PAGE:90-100 kDa, reducing conditions Activity:Measured by its ability to cleave Butyrylthiocholine.The specific activity is >50,000 pmol/min/µg, as measured under the described conditions. Formulation:Supplied as a 0.2 µm filtered solution in Tris-HCl and NaCl.See Certificate of Analysis for details. Molecule Information: Butyrylcholinesterase/BCHE Aliases: Acylcholine acylhydrolase; BCHE; Butyrylcholine esterase; CHE1; Pseudocholinesterase Entrez Gene IDs: 590 (Human); 12038 (Mouse) Background: Butyrylcholinesterase Butyrylcholinesterase (BCHE) is a major acetylcholine hydrolyzing enzyme in the circulation. Although it is present in significant amounts (~3 mg/L) in human plasma, no endogenous physiological substrate has been described for this enzyme. It can degrade a large number of ester-containing compounds in addition to acylcholines. Thus, it is likely to play significant pharmacological and toxicological roles. It is thought to be involved in the pathological process of Alzheimer's disease (AD) by depleting acetylcholine. In contrast to ACHE, it attenuates amyloid fibril formation in vitro. BCHE inhibitors have been used to delay symptoms of AD patients by virtue of their ability to enhance acetylcholine availability. Its involvement in a cholinergic anti-inflammatory pathway connect BCHE and ACHE with a possible marker of low-grade systemic inflammation observed in Type-2 diabetes, obesity, hypertension, coronary heart disease, and AD. BCHE can exist in monomeric and multimeric forms. The expressed recombinant mouse BCHE contains multiple forms that consist of soluble monomers, dimers, and tetramers.