R&D Systems代理6148-DR-025 Recombinant Human Draxin Protein (25 UG)-试剂-金山科研平台

R&D Systems代理6148-DR-025 Recombinant Human Draxin Protein (25 UG)

2025-06-28

货号：6148-DR-025

品牌：R&D Systems

规格：25ug

目录价：￥4490.00

市场价格：￥3592.00

会员价格：￥3592.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Gly26-Val349, with a C-terminal 6-His tag Accession #:NP_940947 N-terminal Sequence Analysis:Gly26 Structure:Monomer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:36.9 kDa SDS-PAGE:50-60 kDa, reducing conditions Activity:Measured by its binding ability in a functional ELISA.

When Recombinant Human Draxin is immobilized at 2 µg/mL, Recombinant Human LRP-6 FcChimera (Catalog# 1505-LR)binds with an apparent K_D<25 nM.

Also measured by its ability toenhance neurite outgrowth of E16-E18 rat embryonic cortical neuron.

Molecule Information: Draxin Long Name: Dorsal Repulsive Axon Guidance Protein Aliases: C1orf187; Neucrin Entrez Gene IDs: 374946 (Human); 70433 (Mouse); 691317 (Rat) Background: Draxin Draxin (Dorsal repulsive axon guidance protein; also neucrin) is a secreted, 58 kDa, presumable glycoprotein member of the draxin family of repulsive guidance proteins. In mammals, it is expressed in neurons (axons), astroglia, and likely cells of the developing somite. Draxin acts as a Wnt antagonist by binding to LRP6. The net effect is to block neural crest migration, and promote the organization of axons into functional tracts or bundles (fasciculation).

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