金山科研平台，产品价格货期咨询微信：jinshanbio Source:E. coli-derived, Ala24-Ala92 Accession #:P50229 N-terminal Sequence Analysis:Ala24 and Pro25 Structure:Monomer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:7.8 kDa SDS-PAGE:8.5 kDa, reducing conditions Activity:Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CCR5.

The ED₅₀ for this effect is typically 0.3 - 1.5 ng/mL.

The two human MIP-1 alpha genes arise by duplication/mutation. They code for MIP-1 alpha isoforms CCL3/LD78a and CCL3L1/LD78b, which share 94% amino acid sequence homology. Whereas the human CCL3/LD78a is a single-copy gene, the human CCL3L1/LD78b gene copy number varies within the population. Human CCL3L1/LD78b binds and signals through chemokine receptors CCR1, CCR5. When compared to CCL3/LD78a, CCL3L1/LD78b has higher binding affinity to CCR5, which also functions as a coreceptor for HIV-1 entry. The copy number of CCL3L1 is one of several genetic determinants of HIV-1 susceptibility.