金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived, Met1-Ile259 Accession #:NP_055236 N-terminal Sequence Analysis:Ser26 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:25.8 kDa SDS-PAGE:32-36 kDa, reducing conditions Activity:Measured in a competitive binding assay. When Recombinant Mouse Kremen-1 (Catalog# 1647-KR)is immobilized at 4 µg/mL (100 µL/well), Recombinant Human Dkk-2 inhibits 50% binding of biotinylated Recombinant Human Dkk-1 (Catalog# 5439-DK)(200 ng/mL) at the concentration range of1.5‑6.0µg/mL. Molecule Information: Dkk-2 Long Name: Dickkopf-2 Entrez Gene IDs: 27123 (Human); 56811 (Mouse) Background: Dkk Family Members of the dickkopf-related protein family (Dkk-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. Dkk-3 and -4 also have one prokineticin domain. Dkk-1, -2, and -4 function as antagonists of canonical Wnt signaling by binding to LRP5/6, preventing interaction of LRP5/6 with Wnt-Frizzled complexes. Dkk-1, -2, and -4 also bind cell surface Kremen-1 or -2 and promote the internalization of LRP5/6. Antagonistic activity of Dkk-3 has not been demonstrated. Dkk proteins have distinct patterns of expression in adult and embryonic tissues and have a wide range of effects on tissue development and morphogenesis. The Dkk family also includes Soggy, which is homologous to Dkk-3 but not to the other family members. Soggy has not been shown to inhibit Wnt signaling, and its role in the pathway is unclear.