金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived, Met1-His936 with a C-terminal 6-His tag Accession #:Q60751 N-terminal Sequence Analysis:Glu31 & Asp742 Structure:Covalently-linked heterotetramers (2 alpha and 2 beta subunits) &covalently-linked single chain homodimers Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:104.5 kDa (single chain), 80.7 kDa ( alpha subunit) & 23.2 kDa ( beta subunit) SDS-PAGE:160-170 kDa, 120-130 kDa & 45-52 kDa, reducing conditions. Activity:Measured by its binding ability in a functional ELISA.

WhenrmIGF-IR is present at0.5 µg/mL, the concentration of rmIGF-I that produces 50% of the optimal binding response is found to be approximately 25 - 100 ng/mL.

IGF-I receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha and two beta subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The alpha subunit of IGF-I receptor is extracellular while the beta subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The IGF-I receptor is highly expressed in all cell types and tissues.