金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived Accession #:O43557 N-terminal Sequence Analysis:Met Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:20.9 kDa SDS-PAGE:25 kDa, reducing conditions Activity:Measured in a cytotoxicity assay using HT‑29 human colon adenocarcinoma cells Yu,K.Y. etal. (1999) J.Biol. Chem. 274:13733; Harrop,J.A. etal. (1998) J.Biol. Chem. 273:27548; Zhai,Y. etal. (1998) J.Clin. Invest. 102:1142.rhLIGHT at 10ng/mL causes a 2-4.5fold inhibition of HT29 proliferation, in the presence of 10U/mL (1ng/mL) rhIFN-gamma.Measured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells. Conn, G. et al. (1990) Proc. Natl. Acad. Sci. USA 87:1323.The ED₅₀ for this effect is typically 1 - 4 ng/mL. Molecule Information: LIGHT/TNFSF14 Long Name: TNF Ligand Superfamily Member 14 Aliases: CD258; TNFSF14 Entrez Gene IDs: 8740 (Human); 50930 (Mouse) Background: LIGHT/TNFSF14 Human LIGHT is a type II membrane protein that is a member of the TNF superfamily (TNFSF14). LIGHT is an acronym that stands for is homologous to Lymphotoxins, exhibits Inducible expression, and competes with HSV Glycoprotein D for HVEM, a receptor expressed by Tlymphocytes. LIGHT has also been called HVEM-L and LT-gamma.