R&D Systems代理6765-PR-050 Recombinant Human PDGF R alpha Fc Chimera Protein, CF (50 UG)-试剂-金山科研平台

R&D Systems代理6765-PR-050 Recombinant Human PDGF R alpha Fc Chimera Protein, CF (50 UG)

2025-06-27

货号：6765-PR-050

品牌：R&D Systems

规格：50ug

目录价：￥4900.00

市场价格：￥3920.00

会员价格：￥3920.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived Accession #:P16234 N-terminal Sequence Analysis:Gln24 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:82.8 kDa (monomer) SDS-PAGE:110-130 kDa, reducing conditions Activity:Measured by its ability to inhibit the biological activity of PDGF-AB or PDGF-AA using NR6R‑3T3 mouse fibroblast cells. Raines, E.W. et al. (1985) Methods Enzymol. 109:749.

The ED₅₀ for this effect is typically0.2 - 1µg/mL in the presence of 100 ng/mL recombinant human PDGF-AB.

Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: PDGF R alpha Long Name: Platelet-derived Growth Factor Receptor alpha Aliases: CD140a; PDGFRA Entrez Gene IDs: 5156 (Human); 18595 (Mouse) Background: PDGF R alpha View PDGF R alpha IHC images. PDGF isoforms exert their cellular effects by binding to the structurally similar receptor tyrosine kinases (RTK), PDGF R alpha (CD140a) and PDGF R beta (CD140b). PDGF-AA, PDGF-BB, PDGF-CC, PDGF-DD and PDGF-AB isofoms bind the two distinct cell surface PDGF receptors with different affinities. Both PDGF R alpha and PDGF R beta are members of the class III subfamily of RTK which are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGF binding induces receptor homo- and heterodimerization leading to signal transduction. The expression of PDGF alpha and beta receptors is independently regulated in various cell types.

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