金山科研平台，产品价格货期咨询微信：jinshanbio Source:Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Leu35-Leu205 (LT alpha ) & Leu54-Gly244 (LT beta ), both with an N-terminal Met & Thr41 ‑ Leu205 (LT alpha ) Accession #:P01374 (LT alpha ) & Q06643 (LT beta ) N-terminal Sequence Analysis:Met & Thr41 (LT alpha ) & Met (LT beta ) Structure:Noncovalently-linked heterotrimer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin Level: Predicted Molecular Mass:18 kDa (LT alpha ), 18.5 kDa ( LT beta ) SDS-PAGE:18-26kDa, reducing conditions Activity:Measured in a cytotoxicity assay using L‑929 mouse fibroblast cells.The ED₅₀ for this effect is typically 0.5‑3ng/mL. Molecule Information: Lymphotoxin Entrez Gene IDs: 4049 (Human); 16992 (Mouse) Background: Lymphotoxins Lymphotoxin-alpha (LT alpha) and Lymphotoxin-beta (LT beta) are members of the TNF superfamily designated TNFSF1 and TNFSF3, respectively. LT alpha is a soluble protein while LT beta is a type II transmembrane protein. Secreted LT alpha will assemble as a homotrimer, LT alpha 3, or as a complex with membrane-associated LT beta to generate two types of heterotrimers, LT alpha 1/beta 2 and LT alpha 2/beta 1. Lymphotoxins are expressed by activated CD4+ T cells, unpolarized IL-2-secreting effector T cells, and Th1 effector cells.