金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived Accession #:Q16620.1 N-terminal Sequence Analysis:Cys32 Structure:Disulfide-linked homodimer Purity:>90%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:71.7 kDa (monomer) SDS-PAGE:120 kDa-130 kDa, reducing conditions Activity:Measured by its ability to inhibit BDNF-induced proliferation of BaF‑TrkB‑BD mouse pro‑B cells transfected with TrkB.The ED₅₀ for this effect is typically 0.1-0.4µg/mL in the presence of 16ng/mL of rhBDNF. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: TrkB Long Name: Neurotrophic Tyrosine Kinase Receptor B Aliases: NTRK2 Entrez Gene IDs: 4915 (Human); 18212 (Mouse); 25054 (Rat) Background: TrkB Members of the Trk family (TrkA, B, and C) of receptor tyrosine kinases act as receptors for the neurotrophin family: BDNF, NGF, NT-3, and NT-4. Trks exhibit selectivity for specific neurotrophins. TrkA, TrkB and TrkC preferentially bind NGF, NT-4 and BDNF, and NT-3, respectively. All Trk family proteins share a common structural organization consisting of an extracellular region with two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains, and an intracellular region that contains the tyrosine kinase domain. They are best known for their regulation of neuronal survival and axon outgrowth.