金山科研平台，产品价格货期咨询微信：jinshanbio Source:Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Met42-Leu1019, with an N-terminal Met and 5-His tag. Accession #:P35559 N-terminal Sequence Analysis:Met Purity:>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 µg per lane. Endotoxin Level: Predicted Molecular Mass:114 kDa SDS-PAGE:95-115 kDa, reducing conditions Activity:Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPPGFSAFK(Dnp)-OH (Catalog# ES005).The specific activity is >1,600 pmol/min/µg, as measured under the described conditions. Formulation:Supplied as a 0.2 µm filtered solution in Tris, NaCl, Brij and Glycerol.See Certificate of Analysis for details. Molecule Information: Insulysin/IDE Long Name: Insulin Degrading Enzyme Aliases: IDE; INSDEGM; Insulinase Entrez Gene IDs: 3416 (Human); 15925 (Mouse); 25700 (Rat) Background: Insulysin/IDE Insulysin, or insulin-degrading enzyme (IDE), is a zinc metallopeptidase of the inverzincin family. IDE is primarily located in the cytosol, but has been detected as a secreted enzyme and associated with the plasma membrane as well. The enzyme is expressed in many tissues, with the highest levels in liver, kidney, brain, and testis. IDE hydrolyzes a variety of regulatory peptides, including insulin, glucagon, atrial natriuretic factor, and transforming growth factor-alpha in vitro>. In addition, IDE has been shown to degrade the amyloid beta (A beta) peptide, which polymerizes into the plaques associated with Alzheimer's disease.