金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived Accession #:NP_005083 N-terminal Sequence Analysis:Tyr Structure:Non-covalently-linked trimer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:19.6 kDa (monomer) SDS-PAGE:21-30 kDa, reducing conditions Activity:Measured by its ability to induce IL-8 secretion in HT1080 human fibrosarcoma cells transfected with GITR. Wyzgol, A. et al. (2009) J. Immunol. 183:1851.The ED₅₀ for this effect is typically 4 - 20 ng/mL. The activity can be enhanced approximately 10-fold in the presence of Mouse Anti-Hemagglutinin/HA Peptide Monoclonal Antibody (Catalog#MAB060). Molecule Information: GITR Ligand/TNFSF18 Long Name: Glucocorticoid Induced TNF Receptor Family Related Gene Ligand Aliases: TNFSF18 Entrez Gene IDs: 8995 (Human); 240873 (Mouse) Background: GITR Ligand/TNFSF18 GITR Ligand (GITRL) is a member of the TNF superfamily and has been designated TNFSF18. The carboxy-terminal extracellular domain shows sequence similarily to TNF-alpha/TNFSF1A, Fas Ligand/TNFSF6, TRAIL/TNFSF10, and TNF-beta/TNFSF1B. GITRL is constitutively expressed in human umbilical vein endothelial cells but is not expressed in resting or stimulated T cell lines, B cell lines or peripheral blood mononuclear cells.