金山科研平台，产品价格货期咨询微信：jinshanbio Source:E. coli-derived, Ser217-Asp384 (Asp285His) (p18 subunit) & Leu385-Asp479 (p10 subunit), with a C-terminal 6-His tag Accession #:Q14790 N-terminal Sequence Analysis:Ser217 (p18 subunit) & Leu385 (p10 subunit) Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin Level: Predicted Molecular Mass:18 kDa & 10 kDa SDS-PAGE:18 kDa and 10 kDa, reducing conditions Activity:Measured by its ability to cleave a fluorogenic peptide substrate Ac-IETD-AFC. The specific activity is >1,000 pmol/min/µg, as measured under the described conditions. Molecule Information: Caspase-8 Aliases: CASP8; Mch5 Entrez Gene IDs: 841 (Human); 12370 (Mouse) Background: Caspases

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.