金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Leu20-Gly320, with a C-terminal 10-His tag Accession #:P15509 N-terminal Sequence Analysis:Leu20 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:36.2kDa SDS-PAGE:60-70 kDa, reducing conditions Activity:Measured by its ability to inhibit GM-CSF-dependent proliferation of TF‑1 human erythroleukemic cells.The ED₅₀ for this effect is typically 1.25 - 5 µg/mL in the presence of 40 pg/mL of rhGM-CSF. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: GM-CSF R alpha Long Name: Granulocyte Macrophage Growth Factor Receptor alpha Aliases: CD116; CSF2R; CSF2RA; CSF2RY Entrez Gene IDs: 1438 (Human); 12982 (Mouse) Background: GM-CSF R alpha The high affinity receptor for granulocyte-macrophage colony stimulating factor (GM-CSF) consists of two subunits; an 80 kDa cytokine-specific alpha-subunit (CD116), and a 120 kDa non-specific, signal transducing beta-subunit (CD131). Analogous with other cytokine signaling mechanisms, CD131 is also shared with the cytokine specific alpha-subunits of the IL-3 and IL-5 receptors. In the absence of CD131, the CD116 alpha-subunit binds GM-CSF with low affinity. GM-CSF receptors are highly expressed on neutrophils, monocytes, oligodendrocytes, megakaryocytes, eosinophils, and myeloid leukemia cells.