金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived, Met1-Gln265 Accession #:NP_619624 N-terminal Sequence Analysis:Ser21 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:27 kDa SDS-PAGE:40-43 kDa, reducing conditions Activity:Measured by its ability to induce activation of beta -catenin response in a Topflash Luciferase assay using HEK293T human embryonic kidney cells.The typical ED₅₀ is8 - 40ng/mL in the presence of 5 ng/mL Recombinant Mouse Wnt-3a (Catalog# 1324-WN). Molecule Information: R-Spondin 1 Long Name: Roof Plate-specific Spondin 1 Aliases: Cristin 3; RSPO1 Entrez Gene IDs: 284654 (Human); 192199 (Mouse) Background: R-Spondin 1 R-Spondin 1 (RSPO1, Roof plate-specific Spondin 1), also known as Cristin 3, is a 27 kDa secreted protein that belongs to the R-Spondin family. R-Spondins regulate Wnt/beta-catenin signaling, most likely by competing with the Wnt antagonist Dkk-1. R-Spondin 1 is thought to contribute to dorsal neural tube development. In humans, rare disruptions of the R-Spondin 1 gene are associated with XX sex reversal (phenotypic male), hermaphroditism, and palmoplantar keratosis. Postnatally, R-Spondin 1 regulates proliferation of intestinal crypt epithelial cells.