R&D Systems代理7268-CT-100 Recombinant Human CTLA-4 Fc Chimera (CHO-expressed), CF (100 UG)-试剂-金山科研平台

R&D Systems代理7268-CT-100 Recombinant Human CTLA-4 Fc Chimera (CHO-expressed), CF (100 UG)

2025-06-28

货号：7268-CT-100

品牌：R&D Systems

规格：100ug

目录价：￥5170.00

市场价格：￥4136.00

会员价格：￥4136.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived Accession #:P16410 N-terminal Sequence Analysis:Ala37 & Met38 Structure:Disulfide-linked homodimer Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:40.1 kDa (monomer) SDS-PAGE:53-58 kDa, reducing conditions Activity:Measured by its ability to inhibit IL-2 secretion by stimulated Jurkat human acute T cell leukemia cells. Linsley, P.S. et al. (1991) J. Exp. Med. 174:561.

The ED50 for this effect is typicallyor 0.03 - 0.15 µg/mL when stimulated with 1µg/mL Recombinant Human B7-1 Fc Chimera (Catalog # 140-B1).

Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: CTLA-4 Long Name: Cytotoxic T-lymphocyte-associated Molecule 4 Aliases: CD152 Entrez Gene IDs: 1493 (Human); 12477 (Mouse) Background: CTLA-4 CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA-4 is up-regulated rapidly following T cell activation and CD28 ligation. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28.

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